Streptocarpus grandis ssp. septentrionalis was originally described from the Chimanimani District, in the eastern Manica Highlands of Zimbabwe but also occurs in Mozambique. It differs from its sister subspecies, Streptocarpus grandis ssp. grandis, by differences in the hairs on the ovary and in having fewer glandular hairs on the inflorescence, has a pale violet to almost white corolla with no throat markings and overall has smaller leaves and flowers.

It occurs some 1000 km away for its sister subspecies. DNA analysis has not been performed on this subspecies (as indicated by the * in the Section species listing) and further comparisons of the two subspecies’ morphology and DNA may indicate that it is a separate species and not only a subspecies.