Streptocarpus muscosus is one of the interesting Madagascan Streptocarpellas, with relatively large and soft leaves with small white flowers. It is caulescent but may not grow fully upright, sometimes being found as a lower creeping plant. In the feature plant above the creeping stems can be seen even while the central stem appears to be more upright.
S. muscosus can be easily confused with Streptocarpus thompsonii, which is also endemic to Madagascar and whose range overlaps. Useful features for separating the species include the following:
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- The flowers of S. thompsonii are an open tube type, tapering to the calyx; those of S. muscosus have a distinct pouch shape on the lower corolla, creating a more rounded look below
- The stems of S. thompsonii are usually mottled with maroon or purple spotting, while those of S. muscosus are unspotted

