Authors: Azad, A. K.; Faysal, Md.; Islam, Fahadul; Begh, Md. Zamshed Aam; Amin, Md. Al; Alam, Syed Mhabub; Sugandha, Nusrat Jahan; Shekh, Md. Noman; Islam, Md. Ashiqul
Publication: Journal of Pharmaceutical Sciences and Research
Year: 2020
Genera: Rhynchotechum

Aims: Bangladeshi rural and hilly areas people have long tradition to use various medicinal plants for treating different
diseases. Phyto pharmacology is always a vital way for drug discovery. Antibiotic resistance is rising as a challenging threat
day by day. Diarrhea and pain are always common problems. Present study was designed to evaluate Analgesic,
Antidiarrhoeal and Antibacterial activities of acetone extracts of stem and leaf of Rhynchotechum ellipticum by different

Methods: The analgesic activity of the samples was studied using acetic acid-induced writhing model in mice. Castor oil induced antidiarrheal activity was observed by Thomas method. And antimicrobial activity was monitored by disc diffusion method.

Results: At higher dose (500 mg/kg), Rhynchotechum ellipticum inhibited 65.79 % and 63.16 % writhing of stem as well as leaf acetone extracts, respectively, compared to standard drug Diclofenac Na inhibited 78.07 % writhing. Further study
needed to find possible active ingredients and mechanism of action as well. At higher dose (500 mg/kg) of the acetone stem
and leaf extracts, significant inhibition 50.58 and 52.87 % of characteristic diarrhoeal feces was observed, respectively, as
well as at lower dose (250 mg/kg) of the both extracst, inhibition 41.37 and 40.22 %. Moderate zone of inhibition was
observed at 250µg/disc and 500µg/disc compare to zone of inhibition at average 38mm of ciprofloxancin at 50µg/disc.

Conclusion: From the above results, it is clear that Rhynchotechum ellipticum showed significant pharmacological
potentiality in different study model. So, it will be very much possible source for an isolating lead compound for curing the
numerous disorders